TRANSFORM-HF

TRANSFORM-HF

Does torsemide reduce all-cause mortality compared with furosemide in patients with heart failure following hospitalization?

Study design: Open-label, pragmatic randomized trial

Population

• Number of patients studied: 2859
• Inclusion criteria: Patients hospitalized with heart failure (regardless of ejection fraction)

Interventions

• Experimental group: Torsemide (n = 1431)
• Control group: Furosemide (n = 1428)

Primary outcome: All-cause mortality in a time-to-event analysis

Conclusion

Among patients discharged after hospitalization for heart failure, torsemide compared with furosemide did not result in a significant difference in all-cause mortality over 12 months. However, interpretation of these findings is limited by loss to follow-up and participant crossover and nonadherence.