CLOVERS

What is the effect of a restrictive fluid strategy compared to a liberal fluid strategy on all-cause mortality before discharge home by day 90 in patients with sepsis-induced hypotension?

Unblinded superiority trial

Adult patients with sepsis-induced hypotension

1563 patients
Adult patients with sepsis-induced hypotension refractory to initial treatment with 1 to 3 liters of intravenous fluid within 4 hours of meeting criteria
Not provided in the summary

Interventions

Restrictive fluid strategy (prioritizing vasopressors and lower intravenous fluid volumes)
Liberal fluid strategy (prioritizing higher volumes of intravenous fluids before vasopressor use)

Primary outcome

No significant difference

Safety outcomes or Adverse Events

Number of reported serious adverse events was similar in the two groups

Conclusion

Among patients with sepsis-induced hypotension, the restrictive fluid strategy that was used in this trial did not result in significantly lower (or higher) mortality before discharge home by day 90 than the liberal fluid strategy.